Eliza Mackenzie was the sixth born and third daughter of Colin Mackenzie, 4th of Mountgerald and Emilia, daughter of Colonel James Fraser of Belladrum. She was the older sister of Major Gordon's maternal grandmother (Isabelle Mackenzie), who married David Dick of Glenshiel. After her husband died in 1833, she remarried Francis Spittal, son of Sir James Spittal of Edinburgh. Francis died unexpectedly shortly after; afterwards; she lived with her youngest son Colin Dick who was involved in the food commodities market in London.
Eliza Spittal died in the German State of Hesse in 1854 at 54.